Scientific Program

Peter Van Keep Lecture

David Sturdee (UK)

Plenary Lectures

Samuel Shapiro (ZA) • Oligognostic mega analysis: the example or HRT and breast cancer
Henry Burger (AUS) • The unpredictable endocrinology of the menopause transition
Howard Hodis (USA) • Why not use HRT for the Primary Prevention of CHD?
Shenker Joseph (IL) • Fertility and pregnancy approaching menopause: from ethical issues to clinical risks
Pier Luigi Benedetti Panici (I) • Modulation of surgical radicality in elder women
Wulf Utian (USA)• Promise and fulfillment – have we oversold disease prevention after menopause?
Claus Christiansen (DK) • The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation – may estrogen be a magic bullet?
Richard Santen (USA) • Estrogen paradox: reduction of BC risk with estrogen as MHT
Socrates Papapoulos (NL) • Treatment of osteoporosis beyond bisphosphonates
Gamal Serour (ET) • Menopause in Islamic cultures.

Debates

At hysterectomy for a benign indication, if the ovaries are alright should they be all left?

Walter Rocca (USA) – Lian Ulrich (DK)

Progestins cause mood disturbances?

Sarah Berga (USA) – Regine Sitruk-Ware (USA)

Is there any place for dietary supplements or ‘natural’ remedies for the relief of estrogen deficiency symptoms?

Edzard Ernst (UK) – Martha Hickey (AUS)

Should estrogen be first line therapy for osteoporosis in the younger patient at risk of fracture?

Maria Luisa Brandi (I) – David Barlow (UK)

HRT causes breast cancer?

Anne Gompel (F) – Pietro Sismondi (I)

Hormones and aging: the end of a myth?

Philippe Bouchard (F) – Jean Michel Foidart (B)

Do the results of the Women’s Health Initative studies have relevance for the assessment of the benefits and risks of postmenopausal hormone therapy?

David F. Archer (USA) – Alastair MacLennan (AUS)

Regulatory Agencies and pharma companies. Where is the equilibrium?

Sergio Pecorelli (I) – James Pickar (USA)

Has estrogen treatment an effect on mental health in women?

Declan Murphy – Malcolm Whitehead

Symposia

TRACK 1: MENOPAUSE: PATHOPHYSIOLOGY AND EPIDEMIOLOGY

1. MENOPAUSE: IMPACT OF CULTURE AND ETHNICITY

KoEn Huang (Taiwan) A multinational survey on sexual
dysfunction of postmenopausal women in Asia
Yu Qi (RC) The characteristics of menopausal transition
in Chinese women
Oscar Shimange(ZA) Menopause: the African perspective
Duru Shah (IND) Metabolic disorders during menopause:
does Indian ethnicity matter?

2. HOT FLUSHES, MORE THAN SYMPTOMS?

Robert Freedman (USA) What are hot flushes?
Pauline Maki (USA) The connection between hot flushes
and memory dysfunction in midlife women
Amos Pines (IL) Hot flushes as a marker for increased
CAD risk
Marco Gambacciani (I) Climacteric symptoms as markers
of cardiovascular disease risk

3. FUNCTIONAL AND DYSFUNCTIONAL ENDOMETRIAL BLEEDING: ROLE OF VASCULAR DYSFUNCTION

David F. Archer (USA) Endometrial bleeding: the role of vascular dysfunction
Steven Goldstein (USA) Imaging of the endometrium in postmenopausal bleeding
Jaime Prat (E) Endometrial assessment histology and the pathologist’s interpretation
Carmine Nappi (I) The treatments: a matter of possibilities, a matter of choices

4. BONE, JOINTS AND OSTEOPOROSIS

Camil Castelo Branco (E) Role of FSH in the pathogenesis
of osteoporosis
Mark Brincat (M) Changes in intervertebral discs with
menopause end effects of HRT
Paulina Villaseca (RCH) Secondary osteoporosis, how to
suspect it, when to refer to a specialist in osteoporosis

5. CURRENT ISSUES IN OSTEOPOROSIS

Tobie de Villiers (ZA) Treatment options in fracture protection: the old and the new
Peyman Hadji (D) Assessment of bone strength: present and future options
Claus Christiansen (DK) The role of markers of bone turnover in clinical practice
Socrates Papapoulos (NL) Poor compliance to therapy: the Achilles heel of osteoporosis treatment

TRACK 2: MENOPAUSE, THE CENTRAL NERVOUS SYSTEM, QUALITY OF LIFE AND SEXUALITY

6. THE MENOPAUSAL BRAIN

Roberta Diaz Brinton (USA) Loss of ovarian hormones leads to decline in glucose metabolism and bioenergetics in brain
Eff Hogervorst (UK) Hormone treatment, cognition and dementia: duration and type of treatment matters
Walter Rocca (USA) Neurologic and psychiatric consequences of early bilateral ovariectomy

7. MENOPAUSE, MOOD AND COGNITION

Myra Hunter (UK) Stress, mood and menopause: the influence of age, lifestyle and cohort effects
Victor Henderson (USA) Midlife hormone exposures and cognitive aging
John Studd (UK) Estrogen treatment for depression in women – are psychiatrists missing something?

8. MENOPAUSE AND SEXUALITY

Margaret McCarthy (USA) Mechanisms of sexual differentiation of the brain
Rossella E. Nappi (I) HSDD in the reproductive life cycle: the impact of early menopause
Svetlana Vujovic (SRB) Effects of body weight on sexuality in menopausal women
Luis Hidalgo (EC) Sexual dysfunction among climacteric women: epidemiological and social aspects

9. THE AGING COUPLE

Johannes Bitzer (CH) The aging male – a health risk or a health resource for the menopausal woman
Bruno Lunenfeld (IL) The hypogonadal male: a model for androgen therapy
Martin Birkhaeuser (CH) Partner’s sexual health problems at menopause and beyond
Alessandra Graziottin (I) Hormones behind pheromones: how to maintain the sexual attraction in the aging couple

TRACK 3: MENOPAUSE, LIFESTYLE, METABOLISM, CARDIOVASCULAR HEALTH AND DISEASE

10. THE CARDIOVASCULAR SYSTEM ACROSS MENOPAUSE AND AGING

Frédéric Chantraine (B) Ultrasound assessment of the intima and media layers of the carotid arteries in menopausal women
Irene Lambrinoudaki (GR) Markers of subclinical cardiovascular disease in healthy postmenopausal women
Giuseppe Rosano (I) Management of cardiovascular risk: a gender-related approach
Konstantinos Tserotas (PA) Menopause, insulin resistance and cardiovascular risks

11. METABOLISM AND OBESITY

Maria Grazia Modena (I) Menopause, metabolic syndrome and HRT
Peter Chedraui (EC) Biological and social aspects of the metabolic syndrome in postmenopausal women
Andrej Milewicz (PL) The fat mass or fat distribution is a cardiovascular diseases predictor in postmenopausal women

12. HYPERTENSION AND CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN

Michael Mendelsohn (USA) Hormone actions in the cardiovascular system: 2011 update
Tabassome Simon (F) Impact of hormone therapy on blood pressure in menopausal women
Stephane Laurent (F) Lowering blood pressure in hypertensive postmenopausal women: a mandatory task for physicians.
Peter Collins (UK) Hypertension management in women: time for action

13. HRT AND CARDIOVASCULAR DISEASE

John Stevenson (UK) Coronary heart disease: the swinging pendulum of HRT
Tomi Mikkola (FIN) Cardiovascular effects of HRT in women with or without hot flushes
PierreYves Scarabin (F) HRT and venous thromboembolism

TRACK 4: MENOPAUSE AND CANCER

14. MENOPAUSE AND BREAST CANCER

Øjvind Lidegaard (DK) Breast cancer incidence: the impact of estrogen and progestogen use
Hermann Schneider (D) Hormonal protection of breast cancer Anne Gompel (F) Progesterone and synthetic progestins and the breast
Serge Rozenberg (B) Treatment for menopausal symptoms in breast cancer survivors

15. BREAST CANCER AND THE GYNECOLOGIST

JeanMichel Foidart (B) Molecular and genetic screening of breast cancer by genomic transcriptomic proteomic and metabolomic
Piero Sismondi (I) Contraception and pregnancy after breast cancer
Bo von Schoultz (S) Breast monitoring during HRT
Franco Guidozzi (ZA) The breast in women who are BRCA gene positive

16. ONCOGENESIS AND GYNECOLOGICAL CANCERS

Alfred Mueck (D) Are estrogen metabolites carcinogenic?
Tommaso Simoncini (I) Undermining the molecular basis of breast cancer progression: sex steroids vs. gonadotrophins
Ludwig Kiesel (D) The role of new cellular regulators (such as miRNA)
Jorge Pasqualini (F) Recent advances in the enzymatic control of estrogens and progesterone in pre- and postmenopausal normal and cancerous breast and endometrium

17. SEX HORMONES AND CANCER PROTECTION

Sven O. Skouby (DK) Oral contraceptives and incidence of cancers
Håkan Olsson (S) HRT and incidence of cancers
Farook Al Azzawi (UK) Sex steroids; colorectal cancer and gallbladder disease
Gianfranco Scarselli (I) Hormonal protection against preneoplastic and neoplastic endometrial lesions in pre- and postmenopausal ages

18. ENDOMETRIAL CANCER – THE CHALLENGE OF SCREENING, DIAGNOSING AND TREATING IN AGING WOMEN

Sciarra John (USA) The mamagmemt of post menopausal bleeding
Caterina Exacoustos (I) Role of ultrasound in the diagnosis and staging of endometrial cancer
Jacques Hamou (F) Hysteroscopy: in the high risk population screening for subclinical adenocarcinoma
Enrico Sartori (I) Endometrial cancer: controversies on surgery on primitive tumor

19. OVARIAN CANCER

Philippe Morice (F) Management of borderline ovarian tumors in peri- and postmenopausal women
Angiolo Gadducci (I) Molecular targeted therapy in ovarian cancer
Peter Kenemans (NL) Oral contraceptives and HRT and ovarian cancer

TRACK 5: THE WOMAN BETWEEN 40 AND 50, PERIMENOPAUSE AND PREMATURE AND EARLY MENOPAUSE

20. FERTILITY AFTER FORTIES

Bill Ledger (UK) Pathogenesis and management of premature ovarian failure
Zeev Shoam (IL) Fertility penetrating into the menopausal period – possibilities and consequences
Donatella Caserta (I) When and why say stop
Zion Ben Raphael (IL) POC and fertility after forties

21. PREGNANCY AT ADVANCED MATERNAL AGE

Gerard H.A. Visser (NL) Pregnancy at advanced maternal age
Enrico Ferrazzi (I) Pre-eclampsia and eclampisa
Howard Carp (IL) Recurrent pregnancy loss in the forties: what are the options?

22. CONTRACEPTION IN WOMEN OVER 40

Erdogan Ertungealp (TR) Contraception after forties
Horacio Croxatto (RCH) Recent advances in emergency contraception
Nilson De Melo (BR) Contraception in bariatric surgery treated women
Nestor Siseles (RA) What is the impact of the use of contraceptive methods on the health of perimenopausal women?

23. PERIMENOPAUSE

Alessandro D. Genazzani (I) The hypothalamic regulation in perimenopausal women
Felice Petraglia (I) Endocrinology, paracrinology and intracrinology of ovarian aging in the perimenopause
Luigi Devoto (RCH) Screening for ovarian insufficiency during perimenopause, does the need exist?
Delfin Tan (RP) Is there a biological basis for the differences in the symptomatology and experience of the menopause among ethnic groups of women?

24. PREMATURE OVARIAN FAILURE

Bart C. Fauser (B) Genetics of age of menopause: novel findings and possible implications
Anna Fenton (NZ) Non-genetic causes of premature ovarian insufficiency
Vera Smetnik (RUS) Molecular and genetic predictors of clinical variants of premature ovarian insufficiency Rodney Baber (A) Lifetime consequences of early menopause
Nick Panay (UK) The management of premature ovarian failure

25. FERTILITY PRESERVATION

Jacques Donnez (B) Fertility preservation: is ovarian tissue cryopreservation and reimplantation the best option?
Antonio Pellicer (E) Fertility preservation in breast cancer patients
Luca Gianaroli (I) The impact of gametes and embryos quality on the outcome of fertility preservation
Paolo G. Artini (I) Vitrification: a promising approach for fertility preservation

26. GYNECOLOGICAL SURGERY

Vito Cela (I) Robotic surgery
Michelle Nisolle (B) Myomectomy vs. uterine artery embolisation vs. hysterectomy
Gianbenedetto Melis (I) Stefano Angioni (I) Deep endometriosis: the surgical challenge

27. UROGENITAL TRACT, PELVIC ORGAN PROLAPSE AND URINARY INCONTINENCE

George Creatsas (GR) Urogenital aging: an old problem recently recognized
Linda Cardozo (UK) Management of the over active bladder syndrome
Mauro Cervigni (I) Pelvic organ prolapse: actual management in over-65 women

TRACK 6: HORMONAL AND NON-HORMONAL TREATMENTS FOR WOMAN’S HEALTH

28. EARLY VS. LATE INTERVENTION WITH STEROID HORMONES AFTER THE MENOPAUSE: AN UPDATE

Francine Grodstein (USA) The Nurses’ Health Study
Howard Hodis (USA) The ELITE Trial
Rogerio Lobo (USA) The KEEPS Trial Agnès Fournier (F) E3N Trial

29. ANDROGENS IN AGING WOMEN

Fernand Labrie (CDN) The physiological basis of androgen deficiency in postmenopausal women
Andrea Genazzani (I) Androgen’s effect on brain and vessels
James Simon (USA) Androgen therapy: impact on sexual function
Susan Davis (Australia) Androgen therapy for women: is it safe?

30. NON-HORMONAL TREATMENT OF MENOPAUSAL SYMPTOMS

Alastair MacLennan (AUS) Death by “natural” causes – potions, poisons and placebos
Julio Morfìn Martin (MEX) Desvenlafaxine for the treatment of vasomotor symptoms
Edzard Ernst (UK) Alternative medicine for menopause
Martin Imhof (A) Postmenopausal depressive and anxiety symptoms after treatment with red clover isoflavones

31. HRT: THE ROUTE, THE DOSE AND THE HORMONES

Robert Reid (CDN) Oral or transdermal therapy: the reason for a choice
Decebal Hudita (RO) Progestogen therapy, the duration
David Serfaty (F) Intrauterine contraception as therapy
Adolf Schindler (D) Should one select the progestogen for HRT?

32. SERMs, SARMs

Charles Sultan (F) SARMs
Santiago Palacios (E) Target tissue and different SERMs
Steven Goldstein (USA) Gynecologic effects of SERMs: not all SERMs are created equal
Tobie De Villiers (ZA) What happened to the promise of SERMs?

33. HORMONES, GENDER AND AGING

Philippe Bouchard (F) Revisiting hormones and aging
Frederick Naftolin (USA) Hormones at the crossroads: gender-specific effects of testosterone and metabolites in aging individuals
Johannes Huber (A) Gender-related medicine and HRT
Franic Damir (SLO) Counseling the perimenopausal women in post WHI era

Meet the expert sessions

Treatment of climacteric symptoms in women with contraindications to hormone

Margaret Rees (UK) – Christopher Haines (HK)

Prevention and treatment of osteoporosis in aging women

Joaquin Calaf (E) – Peyman Hadji (D)

The clinical approach to sexual dysfunction in postmenopausal women

Alessandra Graziottin (I) – Johannes Bitzer (CH)

Urinary stress and urge incontinence: the clinical management

Linda Cardozo (UK) – Rodolfo Milani (I)

Fertility issues in the aging couple

Annibale Volpe (I) – Jehoshua Dor (IL)

Clinical management issues and side-effects from HRT

Henri Rozenbaum (F) – Stefano Lello (I)